Schizophrenia & Evolution

AHS 2017

AHS 2017: Evolution & Schizophrenia


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Complete References

Attard, A., & Larkin, M. (2016). Art therapy for people with psychosis: a narrative review of the literature. The Lancet Psychiatry, 3(11), 1067–1078.

Avramopoulos, D., Pearce, B. D., McGrath, J., Wolyniec, P., Wang, R., Eckart, N., … Pulver, A. E. (2015). Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation. PloS One, 10(3), e0116696.

Bailey, J. M. (2000). How can psychological adaptations be heritable? Novartis Foundation Symposium, 233, 171-80–4. Retrieved from

Baril, L., Ancelle, T., Goulet, V., Thulliez, P., Tirard-Fleury, V., & Carme, B. (1999). Risk factors for Toxoplasma infection in pregnancy: a case-control study in France. Scandinavian Journal of Infectious Diseases, 31(3), 305–9. Retrieved from

Bilder, R. M., & Knudsen, K. S. (2014). Creative cognition and systems biology on the edge of chaos. Frontiers in Psychology, 5, 1104.

Bressan, P., & Kramer, P. (2016). Bread and Other Edible Agents of Mental Disease. Frontiers in Human Neuroscience, 10, 130.

Burns, J. K. (2006). Psychosis: A costly by-product of social brain evolution in Homo sapiens. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30(5), 797–814.

Burns, J. K. (2009). Reconciling “the new epidemiology” with an evolutionary genetic basis for schizophrenia. Medical Hypotheses, 72(3), 353–358.

Calvo, P., Fortuny, J. R., Guzmán, S., Macías, C., Bowen, J., García, M. L., … Fatjó, J. (2016). Animal Assisted Therapy (AAT) Program As a Useful Adjunct to Conventional Psychosocial Rehabilitation for Patients with Schizophrenia: Results of a Small-scale Randomized Controlled Trial. Frontiers in Psychology, 7, 631.

Cascella, N. G., Kryszak, D., Bhatti, B., Gregory, P., Kelly, D. L., Mc Evoy, J. P., … Eaton, W. W. (2011). Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophrenia Bulletin, 37(1), 94–100.

Cederlöf, M., Maughan, B., Larsson, H., D’Onofrio, B. M., & Plomin, R. (2017). Reading problems and major mental disorders - co-occurrences and familial overlaps in a Swedish nationwide cohort. Journal of Psychiatric Research, 91, 124–129.

Chabris, C. F., Lee, J. J., Benjamin, D. J., Beauchamp, J. P., Glaeser, E. L., Borst, G., … Laibson, D. I. (2013). Why it is hard to find genes associated with social science traits: theoretical and empirical considerations. American Journal of Public Health, 103 Suppl 1(Suppl 1), S152-66.

Chiang, M., Natarajan, R., & Fan, X. (2016). Vitamin D in schizophrenia: a clinical review. Evidence Based Mental Health, 19(1), 6–9.

Crow, T. J. (2000). Schizophrenia as the price that homo sapiens pays for language: a resolution of the central paradox in the origin of the species. Brain Research. Brain Research Reviews, 31(2–3), 118–29. Retrieved from

Dauwan, M., Begemann, M. J. H., Heringa, S. M., & Sommer, I. E. (2016). Exercise Improves Clinical Symptoms, Quality of Life, Global Functioning, and Depression in Schizophrenia: A Systematic Review and Meta-analysis. Schizophrenia Bulletin, 42(3), 588–99.

De Santis, A., Addolorato, G., Romito, A., Caputo, S., Giordano, A., Gambassi, G., … Gasbarrini, G. (1997). Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet. Journal of Internal Medicine, 242(5), 421–3. Retrieved from

Dohan, F. C. (n.d.). The possible pathogenic effect of cereal grains in schizophrenia. Acta Neurologica, 31(2), 195–205. Retrieved from

Dohan, F. C. (1988). Genetic hypothesis of idiopathic schizophrenia: its exorphin connection. Schizophrenia Bulletin, 14(4), 489–94. Retrieved from

Endres, D., Dersch, R., Stich, O., Buchwald, A., Perlov, E., Feige, B., … van Elst, L. T. (2016). Vitamin D Deficiency in Adult Patients with Schizophreniform and Autism Spectrum Syndromes: A One-Year Cohort Study at a German Tertiary Care Hospital. Frontiers in Psychiatry, 7, 168.

Eyles, D. W., Feron, F., Cui, X., Kesby, J. P., Harms, L. H., Ko, P., … Burne, T. H. J. (2009). Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology, 34, S247–S257.

Foster, A., Gable, J., & Buckley, J. (2012). Homelessness in Schizophrenia. Psychiatric Clinics of North America, 35(3), 717–734.

Geretsegger, M., Mössler, K. A., Bieleninik, Ł., Chen, X.-J., Heldal, T. O., & Gold, C. (2017). Music therapy for people with schizophrenia and schizophrenia-like disorders. In C. Gold (Ed.), Cochrane Database of Systematic Reviews (Vol. 5, p. CD004025). Chichester, UK: John Wiley & Sons, Ltd.

Gorczynski, P., & Faulkner, G. (2010). Exercise therapy for schizophrenia. The Cochrane Database of Systematic Reviews, (5), CD004412.

Hodgins, S. (2008). Violent behaviour among people with schizophrenia: a framework for investigations of causes, and effective treatment, and prevention. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 363(1503), 2505–18.

Horrobin, D. F. (1998). The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophrenia Research, 30(3), 193–208.

Horrobin, D. F. (2001). The madness of Adam and Eve : how schizophrenia shaped humanity. Bantam.

Kalaydjian, A. E., Eaton, W., Cascella, N., & Fasano, A. (2006). The gluten connection: the association between schizophrenia and celiac disease. Acta Psychiatrica Scandinavica, 113(2), 82–90.

Kavak, F., Ünal, S., & Yılmaz, E. (2016). Effects of Relaxation Exercises and Music Therapy on the Psychological Symptoms and Depression Levels of Patients with Schizophrenia. Archives of Psychiatric Nursing, 30(5), 508–512.

Keller, M. C., & Miller, G. (2006). Resolving the paradox of common, harmful, heritable mental disorders: Which evolutionary genetic models work best? Behavioral and Brain Sciences, 29(4).

Kovács, Z., Kis, R., Rózsa, S., & Rózsa, L. (2004). Animal-assisted therapy for middle-aged schizophrenic patients living in a social institution. A pilot study. Clinical Rehabilitation, 18(5), 483–486.

Kraeuter, A. K., Loxton, H., Lima, B. C., Rudd, D., & Sarnyai, Z. (2015). Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia. Schizophrenia Research, 169(1–3), 491–493.

Kraft, B. D., & Westman, E. C. (2009). Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutrition & Metabolism, 6, 10.

Martin, L. A. L., Koch, S. C., Hirjak, D., & Fuchs, T. (2016). Overcoming Disembodiment: The Effect of Movement Therapy on Negative Symptoms in Schizophrenia-A Multicenter Randomized Controlled Trial. Frontiers in Psychology, 7, 483.

McGrath, J., Saari, K., Hakko, H., Jokelainen, J., Jones, P., Järvelin, M.-R., … Isohanni, M. (2004). Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study. Schizophrenia Research, 67(2–3), 237–45.

McGrath, J., Saha, S., Chant, D., & Welham, J. (2008). Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality. Epidemiologic Reviews, 30(1), 67–76.

Mitra, S., Natarajan, R., Ziedonis, D., & Fan, X. (2017). Antioxidant and anti-inflammatory nutrient status, supplementation, and mechanisms in patients with schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 78, 1–11.

National Collaborating Centre for Mental Health. (2014). Psychosis and Schizophrenia in Adults: The NICE Guideline on Treatment and Management 2014. Retrieved from

Nurenberg, J. R., Schleifer, S. J., Shaffer, T. M., Yellin, M., Desai, P. J., Amin, R., … Montalvo, C. (2015). Animal-Assisted Therapy With Chronic Psychiatric Inpatients: Equine-Assisted Psychotherapy and Aggressive Behavior. Psychiatric Services, 66(1), 80–86.

PACHECO, A., EASTERLING, W. S., & PRYER, M. W. (1965). A PILOT STUDY OF THE KETOGENIC DIET IN SCHIZOPHRENIA. American Journal of Psychiatry, 121(11), 1110–1111.

Pawełczyk, T., Grancow-Grabka, M., Kotlicka-Antczak, M., Trafalska, E., & Pawełczyk, A. (2016). A randomized controlled study of the efficacy of six-month supplementation with concentrated fish oil rich in omega-3 polyunsaturated fatty acids in first episode schizophrenia. Journal of Psychiatric Research, 73, 34–44.

Pearlson, G. D., & Folley, B. S. (2007). Schizophrenia, Psychiatric Genetics, and Darwinian Psychiatry: An Evolutionary Framework. Schizophrenia Bulletin, 34(4), 722–733.

Polimeni, J., & Reiss, J. P. (2003). Evolutionary Perspectives on Schizophrenia. The Canadian Journal of Psychiatry, 48(1), 34–39.

Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. M., … Stefansson, K. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience, 18(7), 953–955.

Puri, B. K., & Richardson, A. J. (1998). Sustained remission of positive and negative symptoms of schizophrenia following treatment with eicosapentaenoic acid. Archives of General Psychiatry, 55(2), 188–9. Retrieved from

Puri, B. K., Richardson, A. J., Horrobin, D. F., Easton, T., Saeed, N., Oatridge, A., … Bydder, G. M. (n.d.). Eicosapentaenoic acid treatment in schizophrenia associated with symptom remission, normalisation of blood fatty acids, reduced neuronal membrane phospholipid turnover and structural brain changes. International Journal of Clinical Practice, 54(1), 57–63. Retrieved from

Rajapakse, R., Mousli, M., Pfaff, A. W., Uring-Lambert, B., Marcellin, L., Bronner, C., … Candolfi, E. (2005). 1,25-Dihydroxyvitamin D3 induces splenocyte apoptosis and enhances BALB/c mice sensitivity to toxoplasmosis. The Journal of Steroid Biochemistry and Molecular Biology, 96(2), 179–185.

Remberk, B. (2017). Clinical significance of psychotic-like experiences in children and adolescents. Psychiatria Polska, 51(2), 271–282.

RÖHRICHT, F., & PRIEBE, S. (2006). Effect of body-oriented psychological therapy on negative symptoms in schizophrenia: a randomized controlled trial. Psychological Medicine, 36(5), 669.

Samaroo, D., Dickerson, F., Kasarda, D. D., Green, P. H. R., Briani, C., Yolken, R. H., & Alaedini, A. (2010). Novel immune response to gluten in individuals with schizophrenia. Schizophrenia Research, 118(1–3), 248–255.

Severance, E. G., Kannan, G., Gressitt, K. L., Xiao, J., Alaedini, A., Pletnikov, M. V., & Yolken, R. H. (2012). Anti-Gluten Immune Response following Toxoplasma gondii Infection in Mice. PLoS ONE, 7(11), e50991.

Severance, E. G., Yolken, R. H., & Eaton, W. W. (2016). Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. Schizophrenia Research, 176(1), 23–35.

Sheikhmoonesi, F., Zarghami, M., Mamashli, S., Yazdani Charati, J., Hamzehpour, R., Fattahi, S., … Hendouei, N. (2016). Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial. Iranian Journal of Pharmaceutical Research : IJPR, 15(4), 941–950. Retrieved from

Silverstein, S. M., Del Pozzo, J., Roché, M., Boyle, D., & Miskimen, T. (2015). Schizophrenia and violence: realities and recommendations. Crime Psychology Review, 1(1), 21–42.

Strobl, J. S., Goodwin, D. G., Rzigalinski, B. a, & Lindsay, D. S. (2012). Dopamine stimulates propagation of Toxoplasma gondii tachyzoites in human fibroblast and primary neonatal rat astrocyte cell cultures. The Journal of Parasitology, 98(6), 1296–9.

Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003). Schizophrenia as a Complex Trait. Archives of General Psychiatry, 60(12), 1187.

Torda, A. (2001). Are cats really the source?, 30(8), 743–748.

Uher, R. (2009). The role of genetic variation in the causation of mental illness: an evolution-informed framework. Molecular Psychiatry, 14(12), 1072–82.

Valipour, G., Saneei, P., & Esmaillzadeh, A. (2014). Serum Vitamin D Levels in Relation to Schizophrenia: A Systematic Review and Meta-Analysis of Observational Studies. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3863–3872.

Vilhauer, R. P. (2015). Depictions of auditory verbal hallucinations in news media. International Journal of Social Psychiatry, 61(1), 58–63.

Wallace, C., Mullen, P. E., & Burgess, P. (2004). Criminal Offending in Schizophrenia Over a 25-Year Period Marked by Deinstitutionalization and Increasing Prevalence of Comorbid Substance Use Disorders. American Journal of Psychiatry, 161(4), 716–727.

Webster, J. P., Kaushik, M., Bristow, G. C., & McConkey, G. a. (2013). Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour? The Journal of Experimental Biology, 216(Pt 1), 99–112.

Whitford, V., O’Driscoll, G. A., & Titone, D. (2017). Reading deficits in schizophrenia and their relationship to developmental dyslexia: A review. Schizophrenia Research.

Yee, J. Y., See, Y. M., Abdul Rashid, N. A., Neelamekam, S., & Lee, J. (2016). Association between serum levels of bioavailable vitamin D and negative symptoms in first-episode psychosis. Psychiatry Research, 243, 390–394.